I understand limiting NPC's to above the age threshold of 52 or completely locking out an NPC from players in order to give the NPC the talent, but is there a chance that certain NPCs might be able to use very special sets of Talents to enhance player experience?
If the short answer is no and there never will be, read no further.
If the answer is maybe, I thought up of two very distinct abilities that might be great for an NPC only talent set.
1: Fortune Telling- NPC's with this ability are able to see paths of destiny or latent talents of those they are telling fortunes for.
The NPC is able to read the possible outcomes or plot hooks a PC is currently under the influence or capable of having and relays a very small tidbit of information cryptically to the PC. If a plot hook is murdering a specific NPC, then the "bones read" or "gods whisper" to the NPC and they relay the message "Blood stains your hands" or "wrought iron meets red iron".
2:Soul Sight: The NPC is capable of seeing the degree of lightness and darkness tinging a soul.
Honestly when I thought of this, I was thinking of this guy...
http://giphy.com/gifs/reaction-adam-sandler-little-nicky-rB54WleXLXyfu
This may be a plot hook trigger if it leads the NPC to offer you to join their religious organization or simply attacks you because they are the crazy beggar on the street.